The peninsula of the Peloponnese (in southern Greece), which is also known as the Morea, was first partly conquered in 1397 CE by die Ottoman Sultan Beyazit I from the Byzantines, and was completely overrun in 1460 by Sultan Mehmet II, who was received as a deliverer by the Greek Orthodox Christian population, then suffering under the rule of the Roman Catholics. In 1698 the Ottomans were complled to cede the Peloponnese to the Venetians, under die Treaty of Carlowitz, but in 1718 it was retroceded to the Ottoman Empire under the Treaty of Passarowitz.

For almost six centuries the position of the Armenian nation (millet) within the Ottoman Empire, was one of relative peace, order, security and prosperity until the genesis, in the 1870s, of the so-called "Eastern Question". The Turco-Russian war of 1877 had resulted in the abortive Treaty of San Stefano, and had brought about the signature of the Cyprus Convention and the Treaty of Berlin. These treaties were supposed to procure more privileges for the Ottoman Armenians, but they were actually intended to enable the Great Powers, in particular Britain and Russia, to interfere in the internal affairs of the Ottoman Empire with the hope of snatching a greater share of the spoils when the Empire ultimately collapsed.

When the Turks made the fateful decision of embracing Islam as their religion, they became a marked people in the eyes of the Christian World, which saw that religion as a great danger to its very existence. The Turks failure, or refusal, to accept Christianity, despite the efforts of Pope Pius II, did not endear them to the Christians of the West; nor did their contribution to the Muslim cause during the great politico-religious upheaval of the Crusades. These religious wars created bitterness, hatred and hostility between Islam and Christianity, which were to last for centuries. Christendom saw Islam as a deviance, a bogey, which, it believed, aimed at eradicating the Christian heritage; and therefore the Ottoman Turks, who had espoused the cause of Islam by taking over the Caliphate, became the object of that Christian hatred and hostility.